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Alfalfa seeds lower low density lipoprotein cholesterol and apolipoprotein B concentrations in patients with type II hyperlipoproteinemia.

Alfalfa seeds lower low density lipoprotein cholesterol and apolipoprotein B concentrations in patients with type II hyperlipoproteinemia.



 

         
  No.  Divisions/Titles for Abstract Details

 
  1 Abstract Title Alfalfa seeds lower low density lipoprotein cholesterol and apolipoprotein B concentrations in patients with type II hyperlipoproteinemia.  
  2 Abstract Source Atherosclerosis, 65, 173-179.  
  3 Abstract Author(s) Mölgaard, J., Von Schenck, H. & Olsson, A. G.   
  4 Article Affiliation Departments of ’ Internal Medicine and ’ Clinical Chemistry, Linkiiping University Hospital, Linkaping (Sweden).  
  5 Abstract Fifteen patients with hyperlipoproteinemia (HLP) (a common disorder. It results from an inability to break down lipids or fats in your body, specifically cholesterol and triglycerides), types IIA (n = 8), IIB (n = 3) and IV (n = 4) were given 40 g of heat prepared alfalfa seeds 3 times daily at mealtimes for 8 weeks with otherwise unchanged diet. In patients with type II HLP alfalfa treatment caused after 8 weeks a maximal lowering of pretreatment median values of total plasma cholesterol (a waxy, fat-like substance that occurs naturally in all parts of the body. Your body needs some cholesterol to work properly)from 9.58 to 8.00 mmol/1 (P < 0.001) and low density lipoprotein (LDL) (Low-density lipoprotein (LDL) is the main player in cholesterol transport to the cells and it has been associated with atherosclerosis development and cardiovascular risk)cholesterol from 7.69 to 6.33 mmol/1 (P < 0.01), which corresponds to decreases of 17% and 18%, respectively. Maximal decrease was 26% in total cholesterol and 30% in LDL cholesterol. In two patients with hypercholesterolemia (also called high cholesterol, is the presence of high levels of cholesterol in the blood. It is a form of high blood lipids and hyperlipoproteinemia (elevated levels of lipoproteins in the blood).)the LDL cholesterol decreased less than 5%.
Apolipoprotein (proteins that bind lipids (oil-soluble substances such as fat and cholesterol) to form lipoproteins. They transport the lipids through the lymphatic and circulatory systems)B decreased in the same period from 2.17 to 1.43 g/1 (P < 0.05) in type II HLP, corresponding to 34% decrease, whereas apolipoprotein A-I did not change. Body weight increased slightly during the first 4 weeks of alfalfa treatment (P < 0.001) probably because of the caloric content in the alfalfa seeds. After cessation of treatment, all lipoprotein concentrations returned to pretreatment levels. We conclude that alfalfa seeds can be added to the diet to help normalize serum cholesterol concentrations in patients with type II HLP (Hyperlipoproteinemia type II, by far the most common form, is further classified into types IIa and IIb, depending mainly on whether elevation in the triglyceride level occurs in addition to LDL cholesterol)
 
  6 Summary Alfalfa and extracts of the plant are known to inhibit absorption of dietary cholesterol and prevent increase of total serum cholesterol.Alfalfa seeds lower plasma cholesterol concentrations by inhibiting the absorption of cholesterol and various sterols from the gastrointestinal tract. The active ingredient in alfalfa are saponins (plant glycosides), which are shown to inhibit diet-induced hypercholesterolemia. Alfalfa saponins bind cholesterol and other sterols in a sterolsaponin addition product and increase faecal excretion of bile acids and neutral sterol in several animals.  
  7 Article Published Date 3-12-1986  
  8
Study Type clinical  
  9
Substances Alfalfa   
  10
Diseases Hypercholesterimia  
  11 Pharmacological Actions Hypocholesteremic  
  12
Link https://goo.gl/XoBpxD  
       

 


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