أضخم موقع علمي صحي موثق في العالم لسعادة العائلة وصحتها, بالعلم والإيمان نبني الميزان

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Antimicrobial activity of Saponins from Medicago sp.: Structure-activity relationship.

Antimicrobial activity of Saponins from Medicago sp.: Structure-activity relationship.



 

         
  No.  Divisions/Titles for Abstract Details
 
  1 Abstract Title Antimicrobial activity of Saponins from Medicago sp.: Structure-activity relationship.   
  2 Abstract Source Phytotherapy Research, 20, 454-457.  
  3 Abstract Author(s) Avato, P., Bucci, R., Tava, A., Vitali, C., Rosato, A., Bialy, Z. & Jurzysta, M.  
  4 Article Affiliation Università degli Studi di Bari Aldo Moro   
  5 Abstract The antimicrobial (killing or inhibiting growth of microorganisms) activity of saponins (class of chemical compounds found in particular abundance in various plant species. )from Medicago sativa, M. arborea and M. arabica against a selection of medically important yeasts, Gram-positive (Gram-positive bacteria are bacteria that give a positive result in the Gram stain test, which is traditionally used to quickly classify bacteria into two broad categories according to their cell wall)and -negative bacteria (Gram-negative bacteria are a group of bacteria that do not retain the crystal violet stain used in the Gram staining method of bacterial differentiation)was investigated. Structure-activity growth inhibitory effects of related prosapogenins and sapogenins are also described. Increasing antibiotic activity was observed going from the saponin extracts to the sapogenin samples, suggesting that the sugar moiety is not important for the antimicrobial efficacy. Activity was especially high against Gram-positive bacteria (Bacillus cereus, B. subtilis, Staphylococcus aureus and Enterococcus faecalis) with M. arabica being the species showing a broader spectrum of action. Discrete antifungal activity was also observed, mainly against Saccharomyces cerevisiae. The observed antimicrobial properties of M. sativa and M. arborea were related to the content of medicagenic acid, while hederagenin seems to contribute to the bioactivity of M. arabica total sapogenins.    
  6 Summary Saponins from alflfa is effective in killing bacteria.The observed antimicrobial properties of M. sativa and M. arborea were related to the content of medicagenic acid, while hederagenin seems to contribute to the bioactivity of M. arabica total sapogenins.    
  7 Article Published Date June-2006   
  8
Study Type invitro  
  9
Substances alfalfa  
  10
Diseases Bacterial infection  
  11 Pharmacological Actions Anti-bacterial  
  12
Link https://goo.gl/2MP8uG   
       

 


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