أضخم موقع علمي صحي موثق في العالم لسعادة العائلة وصحتها, بالعلم والإيمان نبني الميزان

85488195

Chloroform Extract of Alfalfa (Medicago sativa) Inhibits Lipopolysaccharide-Induced Inflammation by Downregulating ERK/NF-κB Signaling and Cytokine Production.

Chloroform Extract of Alfalfa (Medicago sativa) Inhibits Lipopolysaccharide-Induced Inflammation by Downregulating ERK/NF-κB Signaling and Cytokine Production.



 

         
  No.  Divisions/Titles for Abstract Details

 
  1 Abstract Title Chloroform Extract of Alfalfa (Medicago sativa) Inhibits Lipopolysaccharide-Induced Inflammation by Downregulating ERK/NF-κB Signaling and Cytokine Production.  
  2 Abstract Source Journal of medicinal food, 16, 410-420.  
  3 Abstract Author(s) Choi, K.-C., Hwang, J.-M., Bang, S.-J., Kim, B.-T., Kim, D.-H., Chae, M., Lee, S.-A., Choi, G. J., Kim, D. H. & Lee, J.-C.  
  4 Article Affiliation Grassland and Forages Research Center, National Institute of Animal Science, Cheonan, Korea.  
  5 Abstract Alfalfa (Medicago sativa L.) (Alfalfa(Medicago sativa)also called Lucerne, is naturally high in many essential vitamins and minerals, including A, D, E, K, and even the full family of B vitamins; biotin, calcium, folic acid, iron, magnesium, potassium and many others, as well as being very high in protein, especially when dried. It is "The king of all foods"!)is commonly used as a traditional medicine and functional food. This study investigated the anti-inflammatory (refers to the property of a substance or treatment that reduces inflammation or swelling)potential of alfalfa and the mechanisms involved. The chloroform extract of alfalfa aerial parts inhibited lipopolysaccharide (LPS)-((also known as lipoglycans and endotoxins, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria, and elicit strong immune responses in animals)stimulated immune (resistant to a particular infection or toxin owing to the presence of specific antibodies or sensitized white blood cells.)responses more than ether, butanol, or water soluble extracts. Treatment with 1 μg/mL LPS increased nitrite concentrations to 44.3 μM in RAW267.4 macrophages, but it was reduced to 10.6 μM by adding 100 μg/mL chloroform extract. LPS treatment also increased the concentrations of tumor necrosis factor-α, (a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction)interleukin (IL)-6,(is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene) and IL-1β (The cytokine interleukin-1β is a key mediator of the inflammatory response. Essential for the host-response and resistance to pathogens)to 41.3, 11.6, and 0.78 ng/mL in culture supernatants of the cells, but these cytokine levels decreased to 12.5, 3.1, and 0.19 ng/mL, respectively, by pretreating with 100 μg/mL of the extract. ICR mice injected with LPS (30 mg/kg body weight) alone showed a 0% survival rate after 48 h of the injection, but 48-h survival of the mice increased to 60% after oral administration of the extract. Subfractions of the chloroform extract markedly suppressed LPS-mediated activation of the extracellular signal-regulated kinase and nuclear factor kappa-B. Cinnamic acid derivatives and fatty acids were found to be active constituents of the extract. This research demonstrated that alfalfa aerial parts exert anti-inflammatory activity and may be useful as a functional food for the prevention of inflammatory disorders.  
  6 Summary Subfractions of the chloroform extract markedly suppressed LPS-mediated activation of the extracellular signal-regulated kinase and nuclear factor kappa-B. Cinnamic acid derivatives and fatty acids were found to be active constituents of the extract. This research demonstrated that alfalfa aerial parts exert anti-inflammatory activity and may be useful as a functional food for the prevention of inflammatory disorders.  
  7 Article Published Date Feb-2013  
  8
Study Type invitro  
  9
Substances alfalfa  
  10
Diseases inflammation  
  11 Pharmacological Actions anti-inflammatory  
  12
Link https://goo.gl/AquJWS  
       

 


videos balancecure

شاركها مع اصدقائك



اشترك بالقائمة البريدية


التعليقات

لا يوجد تعليقات

أضف تعليقًا

Made with by Tashfier

loading gif
feedback